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Posts Tagged ‘Science’

I’ve noticed that news travels slowly in the South. Maybe it’s the history of cool, early evening  breezes on a front porch, where neighbors would catch up with the news of the day, or maybe it’s just the culture. Everything is slower here, and I’ve come to expect it and actually I’ve come to like it. A little banter before a business transaction never hurt anyone, and in fact it helps keep us human.

Well, it’s not often that my husband says he hasn’t heard about a drug. He is a walking encyclopedia of drugs – their generic and brand names and what they say they can do for one of his patients. I used to quiz the Bride on a shoe box full of flash cards filled with a pharmocopia of drug information that she had to commit to memory in order to practice the art of medicine. Brand and generic name on one side, its prescribed use and complications on the other.

But my brilliant hubby never heard of “Molly.” We just figured this illegal drug hadn’t made its way to our sleepy central VA town. Two people died over the past weekend at a concert in NY, and one died in Boston from a new “club/designer/street” drug named Molly. When we heard this news, I said it must be a type of Ecstasy, and I guessed right.

“Molly is classified as a Schedule One drug by the federal government. That means they believe it has “no currently accepted medical use” and “a high potential for abuse.” So now we know it a very pure form of the club drug MDMA , and when taken with other drugs, including alcohol, it can be fatal. http://www.drugabuse.gov/publications/research-reports/mdma-ecstasy-abuse/what-does-mdma-do-to-brain

And yesterday, we found out that one of our own, Shelley Goldsmith a 19 year old second year UVA student, may have died last Saturday after taking Molly at a rave club in DC.

“Shelley Goldsmith had a full scholarship to U.Va., where she was beginning her sophomore year. She was a Jefferson Scholar and a member of the Alpha Phi sorority. Students remembered their friend by painting the Beta Bridge near campus with the message “Shelley our Shooting Star.”

Her autopsy results haven’t been published yet, but statements from her friends, the people who accompanied her by bus to DC, are becoming public. It may take awhile, even in this digital age, for news to travel, but I hope our kids are listening. My condolences and prayers to her family.

http://www.nbcwashington.com/news/local/Police-Investigating-Molly-Use-in-UVa-Students-Death-Mary-Shelley-Goldsmith-222397561.html

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Picture from her sorority’s tumblr page

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UnknownMy fearless editor of Tangerine Tango asked a question on her Facebook page. Lisa Winkler said,

“The cicadas are gone. What world will they find in 17 years?”

Now I wouldn’t blame you for missing that speech President Obama made at Georgetown University on climate change. After all, there was testimony in the Trayvon Martin case to analyze. His poor teenage girlfriend got the third degree from a jokester defense attorney because she was the last one to speak with him on his way home with Skittles in his pocket and an Arizona Iced Tea in his hand.

And then we had to pull apart the Paula Deen redemption interview with Matt Lauer. He sat back, pompously asking her if she was a racist, digging deep into her Southern gentility. I am glad she has finally hired a PR closer, Judy Smith; the DC crisis manager who is supposedly the inspiration for Scandal’s Olivia Pope. In truth, it’s a show I don’t watch, could somebody bring back The West Wing?

And of course we had some mighty interesting SCOTUS decisions to follow, as the Court seemingly stepped back to the future.

But back to the cicada question…17 years from now will a certain barrier island off the Jersey Shore still be here? Our President decided finally to do something concrete last week about climate change, to bypass an intransigent Congress, and try to save that Blue Marble we call earth! It was an image of Earth -– beautiful; breathtaking; a glowing marble of blue oceans, and green forests, and brown mountains brushed with white clouds, rising over the surface of the moon,”the President said.

Obama talked about carbon emissions but he really focused on water; on rising sea levels and flooding, on depleting our aquifers. Here’s what he said, in a nutshell:

“And we’ll partner with communities seeking help to prepare for droughts and floods, reduce the risk of wildfires, protect the dunes and wetlands that pull double duty as green space and as natural storm barriers. And we’ll also open our climate data and NASA climate imagery to the public, to make sure that cities and states assess risk under different climate scenarios, so that we don’t waste money building structures that don’t withstand the next storm.”

 http://newswatch.nationalgeographic.com/2013/06/27/water-issues-ripple-through-obama-climate-change-speech/

In local news relating to water. two UVA sorority girls were surrounded and attacked by men in plain clothes, with guns drawn, in our upscale shopping center after leaving Harris Teeter with cases of La Croix bottled water and ice cream. Yes, the Alcoholic Beverage Control agents thought they were underage purchasers of beer, while their blue cartons only contained water…still one girl had to spend an afternoon and an evening in jail and they were charged with a felony. Go figure. Maybe before trying to save this blue marble, we should try to find the marbles we’ve lost?

http://mobi.dailyprogress.com/progress/db_/contentdetail.htm?contentguid=QD76VKml&full=true#display

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I was going to do a six-worded, pictorial memoir of Spring so far, but there’s just too much going on right now. No, it’s not a shoe sale at Scarpa, or a fox sighting. Although Bob did spot a juvenile fox strolling around the yard yesterday. I’m talking about the big news coming down from the high court this week, about genes.

The US Supreme Court, while thinking that corporations are just like you and me, has decided that our human genes should stay in the public domain. It’s like saying to a patent attorney, “Get lost!” this red hair is mine and I’m keeping it. Pretty much every scientist I know took a collective sigh of relief after this ruling. However in the Association for Molecular Pathology vs Myriad Genetics case, SCOTUS followed up with a coda –  “(synthetic) cDNA is not a “product of nature,” so it is patent eligible under §101. cDNA does not present the same obstacles to patentability as naturally occurring, isolated DNA segments.”  http://www.supremecourt.gov/opinions/12pdf/12-398_1b7d.pdf

Bob explained it to me this way – Let’s say a musician writes a symphony. He/she, and or their company, can patent that song, the sequence of notes that makes the music happen. But the notes themselves cannot be patented; the violins, the drums, the cello and every instrument used to compose that opus cannot be patented, and must stay in the public domain.

The linchpin of this decision, one that may allow for too many loopholes is the phrase that states only when a researcher creates something that is “…not naturally occurring,” then, and only then will they receive a patent. The Court was considering the genetic sequence, in this case, of the BRCA breast cancer gene.

So on one hand the Court is saying that: gene-coded information is what really matters when it occurs “naturally,” and isolating one gene in a sequence is not inventing something new and therefore NOT patentable; but on the other hand, synthetic “cDNA is different from naturally occurring RNA, even though both hold exactly the same genetic information. ”  This is less of a distinction, and more of a contradiction.

But what can we do? Will it help to stem the tide of all those newly minted MD/PhDs out there from going abroad to continue their research? Will it make genetic testing more affordable, like the testing Angelina Jolie decided to have? I once had a genetic test done when I was pregnant with the Rocker. I was 35 and considered an old lady by medical standards, so we traveled to a research facility in CT where a very young doctor inserted a very big needle into my extremely big abdomen.  Something happened in the lab. They never told us what, and only some of the testing was completed; I didn’t know the sex, and only learned that my baby did not have spina bifida. So, they were all ready to make a repeat appointment for me in the OR – they wanted to do a second amniocentesis.

“…amniocentesis is a procedure used to obtain a small sample of the amniotic fluid that surrounds the fetus to diagnose chromosomal disorders and open neural tube defects (ONTDs) such as spina bifida. There is a small risk of miscarriage associated with amniocentesis which must be balanced with the risk of an abnormality and the patient’s desires.”

I had watched my baby Rocker, on an early ultrasound monitor in 1984, back away from that needle once, and I was not about to do it again. After 3 miscarriages the year before, Bob took one look at me and told the genetic counselor, “Thanks, but no thanks.”

Here is my handsome boy at his sister’s wedding, with all 10 toes and 10 musical fingers.J&M  0602

A little history of US Patent Law from 1793 – http://en.wikipedia.org/wiki/History_of_United_States_patent_law

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We’re not hibernating exactly. It’s just that a weird warm front – the thing we used to call a January thaw – is approaching from the South. Temperatures are supposed to climb into the mid-70s today and continue through the weekend. There is zero visibility here on the mountain, it’s as if we’ve been enveloped by a huge marshmallow, or wrapped up in cotton. Birds won’t fly in these conditions.
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Every now and then I’ve thought I might want to write a science fiction story. More Atwood and less Bradbury, who once said , “Anything you dream is fiction, and anything you accomplish is science, the whole history of mankind is nothing but science fiction.” Of course the best stuff is just ever so slightly removed from reality, one step beyond the norm so that we can easily imagine this dystopia. Hunger Games was just a reality show gone horribly wrong in the future.

I would create a world that is the direct result of Climate Change; one in which the sun delivers 3rd degree burns to our skin in just 3 minutes of direct sun exposure, so that we all become night creatures. If some of us had to go outside during daylight hours, we’d be dressed like an astronaut. Think how we would have to adapt to becoming nocturnal. It would be like the boy in the bubble, only it would be a universal Severe Combined Immune Deficiency Syndrome and planet earth would have to figure out a way to survive.
https://soundcloud.com/legacyrecordings/paul-simon-the-boy-in-the

Warm January days and the news of another asteroid nearly missing us, these will always kick me into fantasy mode, but this story on BBC put me over the edge:” US Shoots Down Death Star Superlaser Petition.” http://www.bbc.co.uk/news/world-us-canada-20997144 Did you know that The White House must respond to any and all petitions that contain more than 25,000 signatures? I guess whoever made that rule didn’t fantasize about the internet? “In a playful response, a senior US government official said the Obama administration ‘does not support blowing up planets.’ The official also said the cost – about $850 quadrillion – was too high.”

Bob just came in from the hot tub. He will often tell me he’s spotted 4 or 5 floating satellites in the early morning or early evening sky; “Space junk” we call it. Without Northeast light pollution, sky gazing in VA can be amazing. Obviously not today. Would you be surprised to hear that NASA tracks about 100,000 objects, some as large as dead satellites in the sky. This “orbital debris” is threatening to make our atmosphere a junkyard. After almost every mission, the space shuttle had to have windows repaired or replaced from collisions with orbital debris.http://www.nasa.gov/audience/forstudents/5-8/features/what-is-orbital-debris-58.html

Space Junk

Space Junk

I told Bob that Bean was chasing a red fox and that he needn’t worry about the Death Star. He said, “OH, good she didn’t catch it did she?”

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I remember the first time I went to see my regular doctor at UVA for a general physical exam. The Bride had recommended him and it turns out he is a real life Dr McDreamy. Handsome and smart, plenty of time to answer my questions, not in any rush to shoo me out the door. Maybe this is what academic medicine is all about? I was surprised that he ordered tests for blood and bone density, mammography – and he didn’t actually touch me. I guess my Irish ancestors get the prize for giving me all the right numbers in blood pressure, and remember I didn’t come in with a problem. But my first surprise was the nursing assessment before Dr McDreamy walked in; she asked me if, “I feel safe at home?”

Bob tells me that this is a relatively new question in the battery of things we patients must divulge when we are putting our lives into the hands of someone. I understood, I suppose if I was a battered and abused woman maybe I’d feel safe enough here to break down and tell? It made me wonder what protocol they use if a woman or man answered that question in a different way. How much do we drink, do we smoke, and btw how do we feel in our home? I remember when Bob worked on a baby who had drowned in a hot tub. I’m pretty sure they weren’t asking questions back then about pools and hot tubs.

Last month I accompanied the Love Bug to her 4 month Peds check-up. How’s the nursing going, sleeping? And political junkie that I am, I thought about the small battle that was waged last year to gag doctors in FL. Legislators there were fighting to silence their pediatricians’ general wellness questions; in particular, one question, “Are there guns in the home?” Yes sir, politics has slipped inside that HIPPA protected wall of the doctor/patient relationship – one I liken to a priest/confessor – and is yet again telling our health care professionals what to do.

“The way some doctors see it, asking patients whether they own a gun is no more politically loaded than any other health-related question they ask. So when a Florida law that prohibited them from discussing gun ownership with patients passed last year, they moved to fight it. A federal judge issued a permanent injunction blocking enforcement of the law in July.” http://www.npr.org/blogs/health/2012/11/27/165985266/taking-aim-at-restrictions-on-medical-questions-about-gun-ownership

I relaxed. I thought this will never do, it just can’t happen, if a federal judge in FL blocked this inane law, then it’s over. But no, it isn’t over.
http://edition.cnn.com/video/#/video/bestoftv/2013/01/09/ac-acosta-gupta-health-care-guns.cnn?iref=allsearch

A little known 5 sentence provision was slipped onto the end of the Affordable Care Act. Legislators agreed to slash the language of the bill until all health care professionals could do was ask about guns – there is to be

NO documenting of their conversation about guns,
NO collection of data on guns, and
NO research on gun ownership as it relates to injuries…

Legislators argued and preened around the policy, taking out the part about doctors being jailed if they so much as ask about guns, or even losing their license. As many as 8 states are still fighting to reinstate this criminal provision. Remember the good old days when all we worried about was a transvaginal ultrasound? http://edition.cnn.com/video/#/video/bestoftv/2013/01/09/ac-acosta-gupta-health-care-guns.cnn?iref=allsearch

Why should we care? 1 in 5 deaths of children in our country under age 20 is directly related to firearms – 1 in 5. In a 2 year study, for children ages 5 – 14, guns were shown to be the third leading cause of death. And now, the powerful NRA has basically stopped all research into this public health and safety problem. Let the newspapers print the names and addresses of gun owners. How many more rights are we willing to give up for the almighty money of the gun lobby?

Here is a picture of the graffiti that has appeared on our new bridge over the Rivanna River. “Love” on one side, and “Peace and Faith” on the other. I hope it stays there for awhile, that free speech travels upriver.
photo

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My heart goes out to my Jersey Shore. Not the one that Snooki made famous. I’m talking about the peninsula between two rivers, the bay bridges that flew our flag after 9/11, the Stone Pony where my son’s band held court, the small businesses, the boardwalks and dunes, the beach clubs, the people. It’s the people, the friends I’ve made who knew me when, who are suffering now and I feel their loss.

In NJ we had to try and keep our kids inside on Mischief Night, the night before Halloween. It was not an easy task, if they wanted to teepee somebody’s tree or throw eggs on another’s car, chances are they managed to succeed. Sandy made mischief of that beautiful coastline with impunity. While watching CNN in Nashville on Nana duty this morning, I see that the Nashville Red Cross is sending volunteers to Tinton Falls, NJ – the same building where thousands stood in line on September 11th. I’ve talked and texted my way through. A tree missed a car by inches, the tide crept one house away. No one has power, no one. I’m thankful the Rocker and Ms Cait evacuated Asbury Park to my MIL’s house; I’m afraid of what they will find when they return today.

But as cabanas floated out to sea, and long generations of fishermen lost their boats, their homes and their livelihood, I was happy to hear that Gov Chris Christie called our President’s response to the storm “outstanding.” http://www.addictinginfo.org/2012/10/30/christie-not-interested-in-photo-op/
“The president was great last night. He said he would get it done. At 2 a.m., I got a call from FEMA to answer a couple of final questions and then he signed the declaration this morning. So I have to give the president great credit. He’s been on the phone with me three times in the last 24 hours. He’s been very attentive, and anything that I’ve asked for, he’s gotten to me. So, I thank the president publicly for that. He’s done — as far as I’m concerned — a great job for New Jersey.”

That’s what Christie said on Mischief Night, yesterday. It’s mad to think of politics during a crisis like this. Sandy’s death toll is now up to 50, and with live wires down and gas lines disrupted, many residents are being urged to stay away a few more days. Sometimes, I feel as if we’re living in a nightmare of gigantic Climate Change proportions. And it doesn’t help that I’m reading “Cloud Atlas,” by David Mitchell http://www.reviewsofbooks.com/cloud_atlas/review/. It’s such a dystopian horror show, encompassing so many time periods, that every so often you think it actually could happen. That’s the trick of sci-fi, cut very close to the truth.

We are genetically altering our food, we can clone mammals, it’s just a few more steps to a Corpocracy – hey, with Citizens United, we’re already there. Today people are searching for an open gas station so they can run generators, if they have them. Tomorrow we may just need Soap so our fabricants can fall asleep. “Certainly the vacant disneyarium was a haunting frame for those lost rainy landscapes.”

So bring it on Halloween, just try and scare me now you sleep-deprived new parents!

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What will be happening on Monday, August 6th at 1:31 am? An Olympic archery competition, or maybe diving? Nope. A tiny 2,000 pound robotic spacecraft, the size of a Mini Cooper, will navigate its way onto the surface of Mars at a cost of $2.5 billion dollars. NASA has named “her” the Curiosity Rover, and she will be touching down “naked” (without any protective wrapping) assisted by a parachute and a sci-fi Sky Crane. The feed of course will be delayed, but you can watch the action on NASA TV http://www.nasa.gov/multimedia/nasatv/index.html or follow her on Twitter https://twitter.com/MarsCuriosity…Twitter, I may just have to join your tribe.

I was listening to this podcast on NPR http://www.npr.org/2012/08/03/158100726/rover-to-look-for-building-blocks-of-life-on-mars with Bob in the car. My first question was why do we always refer to ships and planes, and most vehicles with the feminine pronoun? Is grammatical gender a feminist issue? Romance languages are replete with feminine and masculine inanimate objects, but we English speakers, not so much. Then when the scientists were discussing its mission, to dig deep below the surface in search of frozen water, and possibly find DNA and RNA and proteins that might hint at evidence of life on the planet, I turned to Bob and said, “Wow, if it’s like us, we may have to re-think Scientology!”

The story only gets curiouser. Of course I had to research the whole “7 minutes of terror” theory, when the Curiosity would leave its orbit and descend to Mars – going from a speed of 13,000 MPH to about 200. And I love the personal story of the Entry, Descent and Landing (EDL) team leader, engineer Adam Steltzner. “He has pierced ears, wears snakeskin boots and sports an Elvis haircut.” Here is a guy who was coasting in high school, then descended into the sex, drugs and rock and roll pit that was the Bay Area of the 70s. His first car was a 69 Cadillac hearse and his dad told him he’d never amount to anything but a ditch digger, then one day he’s driving home from a gig and thinks to himself, hey, the constellation of Orion is in a different place than it was earlier. Steltzner starts taking a physics course at the local community college, and the rest is history, or herstory! http://www.scpr.org/news/2012/08/03/33644/crazy-smart-when-a-rocker-designs-a-mars-lander/

“I grew up in an era where space was revered,” he said. “So I think there’s a kind of natural ego drive to be involved in something so sexy. And I came from rock ‘n’ roll, and there’s a lot of sexy in rock ‘n’ roll. So in terms of, really, just what I would need to measure myself, it could have been waste treatment, but I also needed a little bit of sexy.” So here’s to all those women and men, rock and roll scientists and engineers out there, you’re sexy and we know it!

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